Increased weight gain by C-section: Functional significance of the primordial microbiome

http://advances.sciencemag.org/content/3/10/eaao1874?utm_campaign=toc_advances_2017-10-13&et_rid=301803215&et_cid=1602610

 

Abstract

Epidemiological evidence supports a direct association between early microbiota impact—including C-section—and obesity. We performed antibiotic-free, fostered C-sections and determined the impact on the early microbiota and body weight during development. Mice in the C-section group gained more body mass after weaning, with a stronger phenotype in females. C-section–born mice lacked the dynamic developmental gut microbiota changes observed in control mice. The results demonstrate a causal relationship between C-section and increased body weight, supporting the involvement of maternal vaginal bacteria in normal metabolic development.